Peculiarities of serum levels of vascular growth factor and its receptors in dialysis patients
نویسندگان
چکیده
Recent research has shown that VEGF may influence the condition and survival of patients with chronic kidney disease (CKD), including those treated dialysis procedures. Identifying value this factor is important to uncover mechanisms CKD progression improve treatment strategies.
 The present study aimed determine mean serum levels vascular endothelial growth (VEGF) its receptor (VEGF-R) their correlations pro-inflammatory cytokines (TNF-α, MCP-1, IL -6, -8) in stratified by modality Carnivit use.
 Methods. In prospective cohort study, VEGF, VEGF-R, proinflammatory were determined 41 hemodialysis (HD) (group 1) 14 peritoneal (PD) 2), 28 whom Carnivit. assay was performed enzyme immunoassay "SunRise TouchScreen" using IBL International (Germany) test systems. limits normal values (reference range) based on results a 20 conditionally healthy individuals.
 Results. All included had significantly higher compared donors (p=0.006); significant increase mediator observed both HD PD subjects (p=0.002 p=0.007, respectively). resulted decrease (p=0.023) all patients. Subgroup analysis showed (p=0.016) VEGF-R (p=0.005) after therapy. Mean concentrations (p=0.098) (p=0.160) did not differ from subjects.
 A positive correlation between receptors studied before (p < 0.0001).
 direct -8 an inverse MCP-1 After treatment, (0.782, p=0.01) (0.770, remained group 1 (0.829, p=0.03) 2.
 Conclusion. Increased detected blood patients, them -8. Treatment maintenance balance receptors, which we consider effect for inhibition inflammation dysfunction.
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ژورنال
عنوان ژورنال: Ukraïns?kij žurnal nefrologìï ta dìalìzu
سال: 2022
ISSN: ['2616-7352', '2304-0238']
DOI: https://doi.org/10.31450/ukrjnd.4(76).2022.08